Understanding Genetics: DNA, Genes, and Their Real-World Applications

Course No. 1533
Professor David Sadava, Ph.D.
City of Hope Medical Center, Claremont Colleges
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Course No. 1533
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What Will You Learn?

  • Beginning with a cell, explore the physical and chemical environment of a gene.
  • Follow the Human Genome Project's past, present, and future - starting with the 24,000 genes expressed in every human.
  • Explore how scientists can extract DNA from fossils to learn about extinct creatures.
  • Delve into the implications of stem cell research and cloning, and what they could mean for our future.

Course Overview

We use it routinely to cure diseases, solve crimes, and reunite families. Yet we've known about it for only 60 years. And what we're continuing to learn about it every day has the potential to transform our health, our nutrition, our society, and our future. What is this powerful mystery?

It is DNA—deoxyribonucleic acid, the self-replicating material present in nearly all living organisms. Award-winning teacher, author, and cancer researcher Dr. David Sadava unlocks its mysteries in his new course, Understanding Genetics: DNA, Genes, and Their Real-World Applications. He guides us through decades of scientific discovery and the weighty implications for us, as individuals and as a society.

< p>Genetics: The Science of Heredity

How are the traits of an organism—be it a fern or a human father—passed on to its offspring? This course outlines the history of the science of genetics and explains in detail what we have learned in recent decades about the building blocks—DNA.

Dr. Sadava, a working scientist who draws on examples from his own research, shows us how understanding genetics allows us to improve medical treatment and nutrition, vastly improving our health and quality of life.

Understanding genetics is also a critical step toward understanding our human identity. Examining our DNA—how it works and what happens when something goes wrong—enables us to see the roots of how our bodies work, why we get sick, and how traits are passed through families.

Enjoy this rare opportunity to peer over the shoulder of a working scientist; learn how he puzzles through the problems of genetics to find meaningful solutions that can save lives. Dr. Sadava shares cutting-edge research guided by his passion to help laypeople understand the meaning and importance of genetics.

Genetics' Long and Fascinating History

Our understanding of human development has certainly evolved since ancient Greek times, when Aristotle thought that the ingredients in semen were reorganized by menstrual fluid during intercourse to produce an embryo. And as late as the 17th century, Antonie Van Leeuwenhoek thought he saw tiny, fully formed babies when he looked under a microscope at sperm.

Other past civilizations, however, knew more about genetics than we might think. For example, Egyptians successfully bred the date palm 4,000 years ago to improve the quality and quantity of their fruit crop. In Asia and the Near East 3,500 years ago, horses were bred for speed in racing.

But while humans have worked to improve plant and animal characteristics for thousands of years, we've only come to truly understand what genes are made of and how they work during the past century.

Insight into a Puzzle

Understanding genetics is like sitting down to work a massive puzzle. With each piece you examine, think through, and solve, you glean a new and amazing insight into humanity. Put several pieces together, and you can treat or cure a disease, save a developing fetus from a fatal birth defect, catch a criminal, or reunite a family.

DNA, genes, proteins, amino acids, and enzymes are the vocabulary of our being—what goes on inside our bodies and how our genes are expressed. To learn this vocabulary is to be conversant in who we are and what we can become.

To help us understand the role of proteins in DNA, Professor Sadava cites the example of boiling an egg. A protein's shape is sensitive to its surroundings and can be changed by heat. When you boil an egg—made of a protein called albumin—the heat of the water changes the albumin's structure to create a completely different consistency. As Professor Sadava reminds us, "You can't unboil an egg; changes are irreversible." Next time you're making egg salad, just think—you've transformed a protein!

Dr. Sadava loves to tell tales, and the stories he uses to introduce each lecture are the highlight of the course. He weaves in history, true crime, case studies of people with life-threatening diseases, and phenomena from the natural world to make genetics come to life. Then he steadfastly supports each story with explanatory science.

Professor Sadava deftly introduces us to the puzzle that is genetics, and shows how unlocking each piece helps solve significant real-world problems that affect everyone.

Each lecture begins with a helpful story that illustrates the importance of genetics. The course explicitly outlines the connections between the science of genetics and the health-related problems that plague us in modern society, and illuminates how studying genetics can be instrumental in solving those problems.

While Understanding Genetics is a vigorous and briskly paced course, you won't need a background in biology or chemistry. You'll feel challenged, but you won't be left behind. Professor Sadava is passionate about his subject and extremely knowledgeable.

Genetics in the News

Should we allow cloning? How can we treat obesity? Why do different ethnic groups have higher rates of particular diseases than others? Countless questions of biology prompt heated discussions in the classroom, the legislature, and the courtroom. Obtaining a basic and current knowledge of how genetics works helps inform our ideas and opinions on these important issues.

Many of us are touched by diseases caused by genetic mutations or flaws—such as cystic fibrosis, diabetes, cancer, and sickle cell anemia. In the face of life-threatening, debilitating diseases, Professor Sadava gives us hope through research and discoveries made every day in the field of genetics.

He tells the story of one couple whose young son had cystic fibrosis, the most common inherited disease. Genetic testing prior to their next pregnancy enabled them to implant an embryo without the cystic fibrosis genes into the mother's uterus. The result: the couple was able to have a healthy daughter.

Only in the past few decades have scientists begun to discover and isolate the particular genes that cause certain diseases or conditions and to conduct the research that enables us to actually change genetics.

As Professor Sadava reminds us throughout the course, genetics is not destiny. How we grow and develop is strongly influenced by our environment. But understanding genetics provides us with a wealth of information that can help improve the health and quality of life for everyone.

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24 lectures
 |  Average 30 minutes each
  • 1
    Our Inheritance
    From earliest history, humans have bred plants and animals for desirable and productive characteristics. And they have wondered how it all works. Professor Sadava gives us a brief, fascinating history of genetics and introduces us to the three major unifying ideas in biological science, ideas which form the cornerstone of this course. x
  • 2
    Mendel and Genes
    Monk and scientist Gregor Mendel, working in the late 1800s, learned through pea-plant experiments that each parent's characteristics were particulate, that is, chemically independent. His meticulous research—the beginning of modern genetics—languished for nearly 40 years before its value was discovered. x
  • 3
    Genes and Chromosomes
    Where do you find a gene? Within each living cell is a nucleus, within the nucleus is a chromosome, and on that chromosome is the gene. Beginning with the cell, the unit of biological continuity, this lecture describes the physical and chemical environment of the gene. It shows us that you don't have to be a geneticist to figure out genetics, as a group of rabbis in A.D. 500 learned. x
  • 4
    The Search for the Gene—DNA
    How did research on smoking and lung cancer help scientists figure out that DNA, the genetic material, was damaged in the tumor cells? Professor Sadava tells us how scientists first determined what they were looking for and then found the circumstantial evidence that pointed to DNA. x
  • 5
    DNA Structure and Replication
    The double helix model for DNA is one of the most recognizable scientific icons of our time. This lecture details how Watson and Crick built on the work of earlier researchers to solve the puzzle of the structure of DNA—the double helix. x
  • 6
    DNA Expression in Proteins
    Proteins are made up of chains of 20 amino acids ordered in a particular sequence for each protein. Humans cannot produce eight of those 20 amino acids, although we still need them for proper nutrition. Professor Sadava explains what proteins are, how they relate to DNA, and why they're significant to us. x
  • 7
    Genes, Enzymes, and Metabolism
    Enzymes, which are encoded in our genes, are responsible for most chemical conversions in our bodies. An enzyme sends a signal that creates a biochemical pathway for the process of changing something we consume into something else we need or must get rid of. This lecture explains how metabolism is hard-wired into our genes. x
  • 8
    From DNA to Protein
    In 2004 traces of a poison called ricin were found in a U.S. Senate mailroom. Only 1/10,000 of an ounce of ricin can be fatal. Ricin's enzymes inhibit gene expression; as a result, when ricin is introduced to animal cells, the cells die. This lecture explains how gene expression happens. x
  • 9
    Genomes
    The 24,000 genes that are expressed in humans represent only 2 percent of the entire genome. This lecture explains the history of the Human Genome Project, which grew out of scientists' studies on the effects of radiation on the survivors of the atom bombs in Hiroshima and Nagasaki. x
  • 10
    Manipulating Genes—Recombinant DNA
    By studying how bacteria successfully protect themselves from an attacking virus, scientists discovered that bacteria make an enzyme that recognizes a particular DNA sequence in the virus and cuts the DNA strand at that sequence. As a result of this discovery, scientists learned to splice DNA, creating recombinant DNA, which was initially controversial and now holds vast possibilities for the future. x
  • 11
    Isolating Genes and DNA
    Learn how genetics is used to understand and work toward the cure of a particular disease. After methods for analyzing DNA and chromosomes were developed rapidly in the 1980s, the scientific community tried a new approach called reverse genetics. As a result of this work, scientists isolated the gene that is missing in individuals who have muscular dystrophy. x
  • 12
    Biotechnology—Genetic Engineering
    Insulin that treated individuals with diabetes, whose bodies don't create insulin (or enough of it) on their own, used to come from animals. Animal insulin, however, contains a different sequence of amino acids, so some people's bodies rejected it. The method of manufacturing insulin developed at a California hospital is how all insulin used to treat diabetics is now made. x
  • 13
    Biotechnology and the Environment
    We can use bacteria to solve man-made problems, such as landmines, oil spills, toxic waste, and pollution. Scientists are working to genetically engineer organisms whose traits can be useful in cleaning up our world. x
  • 14
    Manipulating DNA by PCR and Other Methods
    What's the real science behind the dinosaurs that come to life in the movie Jurassic Park? Professor Sadava explains how scientists extract DNA from fossils, and what we can learn about ancient creatures from their genes. This lecture also covers DNA sequencing methods. x
  • 15
    DNA in Identification—Forensics
    In the aftermath of the 2004 tsunami in Sri Lanka, hundreds of children were separated from their parents. When several couples were claiming one baby as their own, DNA testing enabled doctors to reunite the real parents with their baby. This kind of testing is frequently used in crime-solving today. x
  • 16
    DNA and Evolution
    Charles Darwin's travels to the Galapagos Islands helped him understand that different species come from a common ancestor. This lecture explains the genetic components of Darwin's theories. x
  • 17
    DNA and Human Evolution
    Sickle cell disease is more frequently found in African Americans than in Caucasians. After studying this incurable condition, scientists discovered that carriers of sickle cell disease were resistant to malaria, a far more life-threatening sickness. Why? In this lecture, Professor Sadava explores the role of genetic adaptation in human evolution. x
  • 18
    Molecular Medicine—Genetic Screening
    How do scientists detect particular genes that cause certain diseases? Professor Sadava details chemical processes used for genetic screening, and gives several examples of successful genetic tests and results. He describes testing for the effects of genes on drug susceptibility as the next frontier in screening technology. x
  • 19
    Molecular Medicine—The Immune System
    George Washington stemmed a smallpox epidemic by ordering his soldiers to be inoculated during an outbreak. Fifty years earlier, the slave Onesimus had advised Cotton Mather, the Puritan minister, of the practice in his homeland of rubbing dried pus from a smallpox carrier onto a cut of a healthy person. This process created antibodies that resisted the disease. Professor Sadava uses these illustrations to explain how our cells fight disease. x
  • 20
    Molecular Medicine—Cancer
    Cancer develops when cells lose control over their normally regulated reproduction. Only 10 percent of cancers are inherited, but it is a genetic disease. This lecture explains how cancer cells are created and how they can be treated. x
  • 21
    Molecular Medicine—Gene Therapy
    So far gene therapy—the process of adding protein-coding DNA and a promoter sequence for its expression to an organism for medical benefit—has experienced some success in animals and small gains in humans. Professor Sadava shares cutting-edge research and experimentation. x
  • 22
    Molecular Medicine—Cloning and Stem Cells
    Stem cells and cloning are both controversial topics in the news. How do they really work? What is the science behind these genetic procedures, and what are their implications for us? x
  • 23
    Genetics and Agriculture
    Just three crops—corn, rice, and wheat—make up two-thirds of the world's food supply. Learn in this lecture how genetic experimentation on grains has resulted in significant increases in crop yields, which has meaningful ramifications for feeding the world's hungry. x
  • 24
    Biotechnology and Agriculture
    Changes in our environment affect the plants we grow and thus the food we eat. Biotechnology has enabled us to manipulate plants to adapt to different conditions, such as tomatoes that grow in salty soil. This final lecture explores the opportunities and controversies surrounding genetically modified plants. x

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  • 24 lectures on 4 DVDs
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  • 184-page printed course guidebook
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Your professor

David Sadava

About Your Professor

David Sadava, Ph.D.
City of Hope Medical Center, Claremont Colleges
Dr. David Sadava is Adjunct Professor of Cancer Cell Biology at the City of Hope Medical Center in Duarte, CA, and the Pritzker Family Foundation Professor of Biology, Emeritus, at The Claremont Colleges. Professor Sadava graduated from Carleton University as the science medalist with a B.S. with first-class honors in biology and chemistry. A Woodrow Wilson Fellow, he earned a Ph.D. in Biology from the University of...
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Reviews

Understanding Genetics: DNA, Genes, and Their Real-World Applications is rated 4.4 out of 5 by 64.
Rated 4 out of 5 by from Still Holds Value? Regarding germ-cell modification, Sadava states (L21): "No one has suggested (human) germ line gene therapy..." But in November 2018 Chinese doctor He Jiankui claimed to have arranged the birth of genetically germ-cell modified twin girls. He has received severe worldwide criticism (including breaking Chinese law). While Sadava had wisely noted in L1 that "genes do not predict what will happen in an organism" in support of this tough stance, it seemed that his 2008 course might be dated. So I repeated it to determine its fate in my library. IN BRIEF: the course allows an excellent basis for understanding these modern issues. IN DEPTH: So is the course dated? It seems to me that understanding genetics starts with this course. Sadava does an excellent job getting us through connections between genome -> transcriptome (RNA) -> proteome (protein phenotype) -> metabalome (biochemical expression of the phenotype) -> phenome (outcomes). He briefly hints at the epigenome (molecules that feedback to the genome to turn genes on or off). With this base, he launches into gene manipulation, biotechnology, and DNA manipulation. Finally, he provides 7 lectures of real world applications in many fields that clarify any accumulated confusion. Sadava ends with a brief discussion of objections to genetic manipulation and notes the precautionary principle: "if any action might cause harm...the onus is on the proponents..." An EXAMPLE raised my own concerns (L11): artificially mutagenized custom DNA was used to create a sweet protein that was "too sweet" because its 3D fit was "too tight" to come off tongue receptors. My immediate reaction was to ask what other sugar receptors, besides the tongue, could it stick to? Might this synthetic DNA product irreversibly clog up the GLUT 4 transporters that take sugar into a starving cell after the insulin signal is received? I don't know if that was even on their laboratory radar. So yes, negative reviewer Prussiantte, I feel your pain. NOT COVERED THIS COURSE: 1.) In 2008, the research method was pretty much to follow a single gene. In 2016, multi-omics was introduced that allows multiple genes to be traced through their layers of biological networks simultaneously; 2.) Darwin's condescending view of Neanderthal man was exploded in 2014. This amused me, as his profile and that of the Neanderthal always seemed similar; 3.) The discovery that the large amount of "junk DNA" may be used to transcribe DNA into sRNA acting at the epigenomic level (see above). PRO: In L3 Sadava notes: "Primary sex...is determined...by the presence of a gene called SRY on the Y chromosome." CON: Not sure of L16's Kimura proposition that calculates that a protein-based allele change rate of 1 per 20 million years is superior to natural selection because this doesn't seem to address the biochemical complexity and multi-gene network needed to assimilate such a protein change.
Date published: 2019-08-05
Rated 5 out of 5 by from Great narration with depth and detail. I watched this lecture with limited backgrounds of biology and it enlightened me with his using of simple language in a concise manner. This is the best science course ever for me.
Date published: 2019-06-12
Rated 1 out of 5 by from Waste of time and money! Dr. Sadava clearly knows his genetics. Unfortunately his research takes him so deeply into the subject that he is unable to come out to the real world and explain things clearly. The first few lectures are an overview of the subject, mostly from an historical perspective. Few things are explained clearly and much of his discourse leaves you hanging, with obvious questions he doesn't address. The remainder of the course involves how genetics is applied in today's world. Much of that is interesting but I bought the course to learn genetics. The rest I can easily get from the Sunday supplement of my local newspaper.
Date published: 2019-04-19
Rated 3 out of 5 by from A good start but would have liked more science I liked this course quite a bit. The introductory lessons on the fundamentals and core mechanisms of genetics was clear and insightful. And the lessons on applied science were eye-opening. However, I felt that the instructor was too eager to jump from the underlying scientific concepts to stories on applied genetics. Although these examples were interesting, I was really hoping for more detailed explanations of the fundamental principles and mechanisms. It almost felt as if the instructor thought that his audience would get bored if they had to absorb too much hard science.
Date published: 2019-04-08
Rated 3 out of 5 by from Good intro to genetics I really enjoyed this course. The professor does a great job at introducing the basics of genetics; including lectures on genes, DNA, base pairs, recombinant DNA, and proteins, to name just a few. While this course covers a lot of ground, I removed one star for the exclusion of any mention of epigenetics. Considering the time he spends on other topics like the 2 lectures on agricultural biotech, it is really inexcusable to not have at least one lecture on epigenetics. He also is pretty wishey-washey on agricultural biotech in general, mentioning "arguments" against GMOs in the last lecture, while not spending any time refuting those arguments. GMOs are the most studied biotech in history. We have been studying them, and using them, for ~30 something years now. His lecture needed to be pro-science, not agnostic. There is a scientific consensus regarding GMO tech. It would have been pertinant for the prof to say as much. So I docked this course another star for that. Overall, it was very interesting though, and I would recommend it to anyone unfamiliar with the basics of genetics.
Date published: 2019-02-05
Rated 5 out of 5 by from Fascinating genetics topics I am very happy I bought it for my own review to teach genetics classes. It is very helpful. Professor David Sadava did an amazing job lecturing the course.
Date published: 2019-02-04
Rated 5 out of 5 by from The Green Revolution, Cancer and More Having studied physics and math but as one who never even took high school biology I found this course absolutely fascinating. Professor Sadava uses his 24 lectures to great effect, bookending the course with a beginning lecture that sets the stage, describing the early domestication of plants and ending with a lecture on biotech and agriculture. As I live in Mexico where Dr. Norman Borlaug developed the initial high-yielding wheat (and later he did the same in India), I found the course approach particularly personal. This is almost a side benefit, as the meat of the course begins with Mendel and goes through the search for DNA, the understanding of genes and chromosomes, breaking the genome code and more. And of course details on the genetic code, manipulating DNA, the ways that this manipulation can be (and is being) used to fight against birth congenital defects and cancer. And more. Sort of science wrapped up in a detective story. Some reviewers have critiqued some of what Dr. Sadava has presented and wished for better, or more accurate, or more in-depth lectures. For me the presentation hit the mark. I learned a lot of things of which I was unaware, and I am in awe of many of the advances that have been made in this field that result in a greater future for mankind. There was just enough technical detail presented that I feel I now have a basis for understanding what is going on in the field, but it was not so deep that I was unable to follow or understand the concepts. Of course those with a rigorous background may well wish for something with more depth. Not being one of those, I salute Professor Sadava for his ability to present a complex subject with enough depth to be well past hand-waving, but not so much as to be incomprehensible to a lay person. The graphics were quite good and really helped me understand what was happening. Professor Sadava’s presentation was not particularly dynamic, but his passion for what he was doing was evident, even so. He made the subject material shine through, quietly.
Date published: 2018-11-17
Rated 5 out of 5 by from A perfect intro to genetics and biotechnology. I am pretty new to this field but recently I’ve been interested in learning more about it, so I bought this course. I truly enjoyed it! I would say, that even if you are familiar with the field it would be a good refresher of the basics. For someone new to the field like me, it’s a great place to start. There were some terms that were a bit hard to grasp, but nothing that a google search can’t handle. This course is about a decade old and there are new discoveries and technologies that have emerge since then. I would love to see a second edition of this course with all the updated material.
Date published: 2018-06-22
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